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Introduction GHK-Cu is the copper(II) complex of the naturally occurring human tripeptide glycyl-L-histidyl-L-lysine, often written Gly-His-Lys or simply GHK

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10.31491/apt.2020.03.014 14 DuanZ

Although in vitro studies with artificial substrates failed to show an impact of the expansion of the polyQ segment of ATXN3 on its DUB activity [37, 73, 74], the insolubility and immobile nature of the inclusions in vivo [75] may make mutant ATXN3 less prompt to locate at the sites at which editing of Ub chains is needed